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existing experiments have determined that physiological standards within the sleeping subject have "changed abruptly" Murray 303 in the forty-five minutes that follow the onset of Stage IV. Indications of this are that the EEG reading is maladjusted and the eyes flit from one side to the other in a rapid fashion, which is indicative of REM sleep.
Clearly, those with sleep apnea that have difficulty entering or staying within Stage IV indicates fragmented or disturbed sleep patterns. As a result, researchers are "becoming increasingly aware of the adverse effects of sleep deprivation" Weck 12 due to obstructive sleep apnea.