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any of these, only that the witches were responsible.
There are other examples also, that the Elizabethan audience would consider the witches responsible for, like Macbeth's lack of fear, disturbed behaviour, indifference to life and also invitation to evil spirits.
When focusing mainly on the supernatural details of the play, the witches seemed to me as the most powerful element of the play, otherwise, Macbeth seemed like a power-hungry mad murderer, but again, this is only my opinion. The Elizabethan audience would almost definitely consider the witches to be the most powerful element into the play.