To what extent has the love potion affected the relationship between Helena and Hermia? Hermia and Helena"s relationship has changed greatly after the intervention of Puck with the love potion. Once best friends, they have become each others enemies, and all for the love of Lysander and Demetrius. Hermia and Helena were best friends when they were at school. "All school-days" friendship, childhood innocence?" Act 3, Scene 2, Line 201, Helena They had complete trust in each other, telling each other their deepest secrets. "Is all the counsel that we two have shared, The sisters" vows, the hours that...
Helena disappeared, everything would be fine. "Why, get you gone. Who is"t that hinders you?" Act 3, Scene 2, Line 317, Hermia

Helena also has the solution of running away, but can"t as she foolishly still loves Demetrius.

Helena and Hermia"s relationship has changed completely, entirely because of the effect of the love potion on Lysander and Demetrius. The friendship shown before the argument contrasts greatly to the hostility afterwards. The change has been for the worse, completely destroying the women"s trust in each other, and all because of a fight between two men, caused by a mischievous spirit.